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When your partner has no interest in sex despite your best efforts, it's easy to become perplexed. And without guidance, partners may characterize the problem in ways that can destroy the relationship.

Sex: What Problem?

Kelly seemed to have it all. A loving mother of three and a public-relations executive in Manhattan, she had a handsome and charming partner who was a successful entrepreneur. They jetted off for vacations in the Caribbean and dined in the finest restaurants. But their relationship floundered in one intractable area. .

"After a while," Kelly says, "he just stopped wanting to have sex. He'd go months without even touching me."

It's a subject that's full of shame: low sex drive. When your partner has no interest in sex despite your best efforts, it's easy to become perplexed. And without guidance, partners may characterize the problem in ways that can destroy the relationship.

In a society saturated with sexual imagery, it seems strange that some people have no desire for sex. But it is a startlingly common problem. Millions of people suffer from a condition known as hypoactive sexual desire (HSD), about 25 percent of all Americans, by one estimate, or a third of women and a fifth of men. Sex researchers and therapists now recognize it as the most common sexual problem.

In recent years, experts have turned their attention to the causes of low sexual desire, and sex therapists are working on strategies to treat it. Although there is a 50 percent positive outcome in treatment of hypoactive sexual desire, many of those who have HSD don't seek help. This is usually because they don't realize it's a problem, other issues in the relationship seem more important or they feel ashamed.

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Many couples in conflict may have an underlying problem with sexual desire. When desire fades in one partner, other things start to fall apart.

How little is too little?

For Pam, happily married and in her forties, her once healthy sexual desire simply disappeared about six months ago. "I don't know what has happened to my sexual appetite," she says, "but it is like someone turned it off at the switch." She and her husband still have sex, maybe once every few weeks, but she does it out of obligation, not enthusiasm.

When your partner has no interest in sex, partners may characterize the problem in ways that destroy the relationship."I used to enjoy sex," Pam says. "Now there's a vital part of me that's missing."

Ordinary people aren't in a constant state of sexual desire. Everyday occurrences "fatigue, job stress, even the common cold" can drive away urges for lovemaking. Usually, however, spending romantic time with a partner, having sexual thoughts or seeing stimulating images can lead to arousal and the return of a healthy sex drive.

Yet for some people, desire never returns, or was never there to begin with. Frequently, even healthy sexual fantasies are virtually nonexistent in some people who suffer from HSD.

Just how little sex is too little? Sometimes, when a partner complains of not having enough sex, his problem may actually be an unusually high sex drive. Experts agree that there is no daily minimum requirement of sexual activity. In a British survey, published in the Journal of Sex and Marital Therapy, 24 percent of couples reported having no sex in the previous three months. And the classic study, Sex in America, found that one-third of couples had sex just a few times a year. Although the studies report frequency of sex, not desire, it's likely that one partner in these couples has HSD.

One tiny pill

Years ago, another sexual problem "erectile dysfunction" received a sudden burst of attention when a medical "cure" hit the shelves. Before Viagra came along, men with physically based problems suffered impotence in silence, and without much hope. Now many couples enjoy a renewed reservoir of passion.

Obviously, any pill that relieves hypoactive sexual desire would be wildly popular. Unfortunately, the causes of HSD seem to be complex and varied; some sufferers might be treated with a simple pill, but most will likely need therapy -- not chemistry.

One common source of reduced sexual desire is the use of antidepressants known as selective serotonin reuptake inhibitors. SSRIs have been found to all but eliminate desire in some patients. Antidepressants such as Prozac (Fluoxetine) and Zoloft (Sertraline) are among the most widely prescribed drugs for treating depression. Yet one distressing side effect is a drop in sex drive. Some studies indicate that as many as 50 percent of people on SSRIs suffer from a markedly reduced sex drive.

Researchers believe that SSRIs quash the libido by flooding the bloodstream with serotonin, a chemical that signals satiety. "The more you bathe people in serotonin, the less they need to be sexual," says Joseph Marzucco, MSPAC, a sex therapist practicing in Portland, Oregon. "SSRIs can just devastate sexual desire."

Fortunately, researchers are studying antidepressants that act through other channels. Bupropion hydrochloride (Wellbutrin), which enhances the brain's production of the neurotransmitters dopamine and norepinephrine, has received extra attention as a substitute for SSRIs. Early studies suggest that it may actually increase sexual desire in test subjects. A study reported last year in the Journal of Sex and Marital Therapy found that nearly one-third of participants who took bupropion reported more desire, arousal and fantasy.