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Page 1 of 2 CABF policy director on the importance of properly diagnosing bipolar disorder in children and the antidepressants-suicide controversy.
Comments by CABF Research Policy Director, Martha Hellander at American Academy of Child & Adolescent Psychiatry, Town Meeting, Washington, DC. (AACAP 2004 Annual Meeting)
Hello, and thank you for inviting me today. I should start by saying that I have no conflicts of interest other than being a mom. I am also the Research Policy Director and co-founder of the Child & Adolescent Bipolar Foundation, a nonprofit advocacy group of nearly 25,000 families raising children diagnosed with, or at risk for, bipolar disorder. Over half of our children are under the age of 12, more than half of them have been hospitalized anywhere from 1 to 10 times, and about a third of them take antidepressants along with mood stabilizers. Many of our members reported in an informal poll last January, as we testified before the FDA, that their children had been suicidal from a very young age, often before taking any medications; others were never observed by their parents to be suicidal until soon after taking antidepressants, and among those families, about half report that the suicidal behavior stopped when the medication was removed.
CABF does not take a position on whether individual cases were or were not caused by antidepressants. Our position is that mood disorders in children are a major public health crisis, and antidepressants are an essential part of treatment for SOME, but not all, of those kids. CABF welcomes the FDA attention, and increased warnings, being added to the labeling of these medications. As we say at CABF, these are powerful and potentially dangerous drugs that are used of necessity to treat powerful and extremely dangerous illnesses.
Doctors and parents must keep in mind that symptoms of depression in a child may not be a one-time episode, but a manifestation of a developmental stage of a lifelong, hereditary illness such as bipolar disorder in which more time is typically spent depressed than manic or schizophrenia. Parents need to know that depression is often the first sign of bipolar disorder, and is also the most common symptom seen in adolescents during the five years prior to the first psychotic break in schizophrenia. So how can we tell which kid presenting with depression is likely to respond well, or have an adverse reaction to, a particular medication? We can't at this time. We can recognize depression in even preschoolers now, but we don't yet know how to match up which kids with which treatments.
To parents demanding an answer, and God knows how badly we want answers, you must stand firm and say "I don't know." We need you to be honest and tell us frankly that if you conclude that our children are depressed, you have no way of telling whether it is the type of depression likely to respond to an antidepressant, or to psychotherapy, or whether the medication might provoke the child to become manic, or go into a mixed state (which is the highest period of risk for suicide in those with bipolar disorder). And until we have a major federal investment into research on these questions, you will have no answers. To quote the Dali Lama, "Wisdom is the ability to tolerate ambiguity." In other words, don't give us false assurances.
Many parents aren't going to like this ambiguity, of course. They want you to reassure them that it is probably nothing serious, that you're confident the child will grow out of it, and they will look back in a couple of years and laugh at how worried they are now. Please do not sugar-coat the implications of depression in a child. You must deliver the bad news, unvarnished, and lay out the worst case scenario, as well as the best case scenario, and admit to parents that you don't know whether this or that treatment will help the child. It is essential that parents hear from you, and from advocacy groups such as CABF, that suicide is a possible outcome of depression itself in children. This fact is not widely known, and until it is, the public will continue to assume that suicides that occur while a patient is on antidepressants were caused by the drug. Large clinical trials were not designed to tell, in individual cases, what happened. Large group statistics do not identify the lives lost, or the lives saved, at an individual level.
Screen the child for mania. Use the Young Mania Rating Scale - Parent Version on our web site; a group led by Mani Pavuluri is presenting a child mania rating scale at this conference on Saturday afternoon. CABF will encourage parents to do this screening at home, so you may find parents coming in more educated than before. This is good. Parents ignorant of the symptoms of mania will not call manic behaviors to your attention unless you ask; we tend to be proud of our young kids who stay up late writing poetry, or plays, or making art projects, and admire their bravery and adventuresome nature as they climb to the top of the tallest tree or go fearlessly headfirst down the slide over and over again. We are not likely to mention that our kids rarely sleep at night, or won't stop talking from morning until night, unless you ask us.
Take a family history. You may discover that this child's family, on both sides, has many individuals with bipolar illness or schizophrenia. Educate parents as to why it might make sense to starting a depressed child with some manic tendencies and a family history of bipolar disorder on one of the mood stabilizers known to reduce the risk of suicide, such as lithium, before starting the child on an antidepressant.
Monitoring. This is the latest intervention to prevent suicide by children on antidepressants that has taken the country by storm - it is called "monitoring." Is there evidence about how effective it is, of what it consists? In what environment? Is the concept of monitoring likely to induce a false sense of security?
I have asked several parents whose children took their lives what sort of "monitoring" might have saved them. I was told about the teenage boy just out of the hospital whose parents pleaded with the doctor and insurance company to keep him over the weekend. He was started on medication, discharged over their objections, and told by the doctor to just "go home and have a low-key weekend" and report for day hospital on Monday. They made it through Friday night, and Saturday, and Saturday night, one or the other of them always by his side, even sleeping with him at night. Come Sunday, the father had to run an errand, and the mother needed to use the bathroom. During a few moments alone, the boy stole the car keys and the car, disabled the family phone, and drove off to end his life. Does this mean that during monitoring, parents should not leave the house to buy food, or go to the bathroom? And how many adults must be present; what options are there for single parents, or with other young children to care for, or working parents?
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