Addiction to prescription opioids can lead to heroin use. Many who misuse prescribed opioid pain medication turn to heroin as a substitute (Over-prescription of Opioid Painkillers: A Deadly Problem). 12.5 million people misused prescription medication in 2015 and 15,281 people overdosed on commonly prescribed medication, according to the United States Department of Health and Human Services. Do you still think the United States opioid epidemic includes only street people shooting up heroin? Do you know the real connection between opioids and heroin?