Depression and low self-esteem can be closely connected, and boosting your self-esteem when they both appear can be difficult. When you live with low self-esteem for a long time, you may come to believe that you are inherently worthless, and this deep sense of worthlessness is a common symptom of depression. Conversely, if you’ve lived with depression for a long time, your self-esteem can be impacted. Perhaps when the motivation and energy are drained out of you, you lose confidence in your abilities and value. Boosting your self-esteem then can be particularly challenging.