The Effects of Diseases, Drugs, and Chemicals on the Creativity and Productivity of Famous Sculptors, Classic Painters, Classic Music Composers, and Authors - Effects of Chemicals on Creativity

Written by Paul L. Wolf MD

There is an increasing concern about the use of thujone substances with the rise in popularity of herbal medicines. Wormwood oil, which contains thujone, is present in some herbal preparations used to treat stomach disorders and other ailments. (In fact, wormwood, a relative of daisies, got its name from its use in ancient times as a remedy for intestinal worms.) Individuals ingesting these preparations have complained of developing yellow vision.²⁷ Scientific studies of thujone are investigating the active ingredients in many herbal preparations. Absinthe is still manufactured in Spain and the Czech Republic. In modern absinthe, alcohol, which makes up three quarters of the liqueur, may be the most toxic component. It is still illegal to buy absinthe in the United States, although it can be obtained through the Internet or when traveling overseas.

Recently, an article entitled "Poison on Line: Acute Renal Failure Caused by Oil of Wormwood Purchased Through the Internet" was published in the New England Journal of Medicine.²⁸ In this article, a 31-year-old man was found at home in an agitated, incoherent, and disoriented state by his father. Paramedics noted tonic-clonic seizures with decorticate posturing. His mental status improved after treatment with haloperidol, and he reported finding a description of the liqueur absinthe at a site on the World Wide Web entitled "What is Absinthe?" The patient obtained one of the ingredients described on the Internet, essential oil of wormwood. The oil was purchased electronically from a commercial provider of essential oils used in aromatherapy, a form of alternative medicine. Several hours before becoming ill, he drank approximately 10 mL of the essential oil, assuming it was absinthe liqueur. This patient's seizure, probably caused by essential oil of wormwood, apparently led to rhabdomyolysis and subsequent acute renal failure.

This case demonstrates the ease of obtaining substances with toxic and pharmacologic potential electronically and across state lines. Chinese medicinal herbs, some of which can cause acute renal failure, are easily procured by means of the Internet. Although absinthe liqueur is illegal in the United States, its ingredients are readily available. Absinthe is also currently a popular drink in the bars of Prague, in the Czech Republic. The essential ingredient in this ancient potion was purchased in this case by means of up-to-the-minute computer technology.

A modern clinical chemistry and genetics laboratory could possibly have determined the following in van Gogh's case: (1) serum digitalis concentration, (2) serum thujone concentration, (3) urine porphobilinogen, and (4) serum lithium levels. These tests could possibly have confirmed that van Gogh suffered from chronic digitalis intoxication or intoxication from thujone related to excessive drinking of the liqueur absinthe. Modern tests could analyze his urine for the presence of porphobilinogen, which is the diagnostic test for acute intermittent porphyria, another speculated van Gogh illness. If Van Gogh had used lithium carbonate for bipolar illness, serum lithium levels might also have been important to monitor.

LOUIS HECTOR BERLIOZ AND THOMAS DE QUINCEY

Effects of Opium on Their Creativity and Productivity

Hector Berlioz (1803-1869) was born in France. His father was a physician who taught his son to appreciate classic literature. Berlioz's family attempted to interest him in studying medicine, but after his first year of medical school in Paris, he gave up medicine and became a music student instead. Berlioz entered the Paris Conservatoire of Music in 1826. As a boy, Berlioz adored both music and literature, and he went on to compose the Symphonie Fantastique, in which the hero (a thinly disguised representation of Berlioz himself) supposedly survives a large dose of narcotic. Another interpretation of the Symphonie Fantastique is that it describes the dreams of a jilted lover (Berlioz), possibly attempting suicide by an overdose of opium. This work is a milestone marking the beginning of the Romantic era of music.²⁹ His creativity was fired in particular by a love for great literature and an unquenchable passion for the feminine ideal, and in the best of his works these elements conspired to produce music of exquisite beauty.

Berlioz took opium to relieve agonizing toothaches, but there is no indication that he ever took opium to become intoxicated, as the author De Quincey did. On September 11, 1827, Berlioz attended a performance of Hamlet at the Paris Odéon, in which the actress Harriet Smithson (Berlioz later called her Ophelia and Henrietta) played the role of Ophelia. Overwhelmed by her beauty and charismatic stage presence, he fell desperately in love. The grim program of Symphonie Fantastique was born out of Berlioz's despair because of the unrequited love he had for the English Shakespearean actress Harriet Smithson.

Berlioz found a way to channel the emotional upheaval of "l'Affaire Smithson" into something he could control, that is, a "fantastic symphony" that took as its subject the experiences of a young musician in love. A detailed program Berlioz wrote prior to a performance of the Symphonie Fantastique, and which he later revised, leaves no doubt he conceived of this symphony as a romantically heightened self-portrait. Berlioz did eventually woo and win Miss Smithson, and they were married in 1833 at the British Embassy in Paris.

The program Berlioz wrote for Symphonie Fantastique reads, in part:

A young musician of morbid sensibility and ardent imagination in a paroxysm of love-sick despair has poisoned himself with opium. The drug too weak to kill plunges him into a heavy sleep accompanied by strange visions. His sensations, feelings, and memories are translated in his sick brain into musical images and ideas.

The underlying "theme" is obsessive and unfulfilled love. The symphony reflects Berlioz's hysteric nature with fits of frenzy, as revealed in his dramatic behavior (Figure 7 ).²⁹

article acknowledgments