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Medline Research on the Borderline Personality Disorder |
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Written by Dr. Leland Heller
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May 03, 2007 |
A + A - RESET
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Page 7 of 18
Am J Drug Alcohol Abuse 1993;19(4):491-7
"Substance abuse in BPD"
"Substance abuse appears to be a devastating complication in the patient with BPD."
Int J Eat Disord 1993 Dec;14(4):403-16
"Comorbidity of DSM-III-R eating disorders and personality disorders"
Bulimia nervosa with BPD, anorexia nervosa with Avoidant PD. "Eating disorders with personality disorders are characterized by chronicity and low levels of functioning compared with eating disorders with personality disorders."
J Psychol 1993 Nov;127(6):657-76
"Relationship of childhood sexual abuse to BPD, posttraumatic stress disorder, and multiple personality disorder"
A convincing relationship exists between childhood sexual abuse and BPD, posttraumatic stress disorder and multiple personality disorder.
Comp Psychiatry 1993 Nov-Dec;34(6):402-5
"Clozapine treatment of borderline patients: a preliminary study."
Clozapine is effective for atypical psychotic symptoms in some BPD patients.
Compr Psychiatry 1993 Nov-Dec;34(6):418-23
"Diagnosis and clinical features of BPD in the east and west: a preliminary report"
BPD is present in Japan and is the same basic disorder. Differences include a low incidence of substance use disorders, and the maintenance of a "stormy one-to-one or masochistic relationships with their parents because they live at home."
J Behav Ther Exp Psychiatry 1993 Sep;24(3):261-7
"The behavioral treatment of self-starvation and severe self-injury in a patient with BPD"
Self-starvation can be a form of self-injury.
Jpn J Psychiatry Neurol 1993 Mar;47(1):37-46
"Relationship between clinical symptoms and EEG findings in BPD"
No specific diagnostic EEG findings, however abnormalities were found.
Eur Neuropsychopharmacol 1994 Dec;4(4):479-86
"A trial of carbamazepine (Tegretol) in BPD"
No significant positive results were found as a first choice pharmacological treatment. (Note: that has been my experience as well. It only works for those who need it when they've been on an SSRI for at least a week - Prozac has been the most consistently successful medication to combine with Tegretol. L Heller, MD)
Psychiatry Res
"Temporal glucose metabolism in BPD"
"Underlying organic factors such as epilepsy are suspected because clinical characteristics of the syndrome are similar to some manifestations of patients with complex partial seizures." No PET scan data to show temporal lobe epilepsy. (Note: This study does not preclude small areas in the limbic system that are having seizures that extend at times to the temporal lobes during severe dysphoria (anxiety, rage, depression and despair). L. Heller, MD)
Sante Ment Que 1994 Fall;19(2):117-29
"Suicide in patients with BPD"
Long term research shows about 10% will eventually complete suicide. The authors suggest that suicide prevention should not be the major priority of therapy.
Am J Psychiatry 1994 Feb;151(2):277-80
"Serotonergic sensitivity in BPD: preliminary findings"
Malfunction in the serotonin system is found in the BPD. (Note: low levels are not necessarily the same thing as a malfunction. L Heller, MD)
Child Abuse Negl 1994 Jan;18(1):97-101
"Childhood sexual abuse and BPD in eating disorders"
Childhood sexual abuse at less than 14 years old is associated with BPD patients with eating disorders.
Neuropsychopharmacology 1994 Feb;10(1):21-8
"Positron-emission tomography and personality disorders"
A significant decrease in frontal cortex metabolism was seen in the BPD. (Note: this finding is further evidence of physical abnormalities, although the significance of this particular finding is unclear. It may be related to the frequent complication of head injuries. L Heller, MD)
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Last Updated( Feb 04, 2009 )
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reviewed by: Harry Croft, MD
Psychiatrist, HealthyPlace.com Medical Director
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