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Medline Research on the Borderline Personality Disorder |
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Written by Dr. Leland Heller
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May 03, 2007 |
A + A - RESET
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Page 4 of 18
Arch Gen Psychiatry 1988 Feb;45(2):111-9
"Pharmacotherapy of borderline personality disorder. Alprazolam, carbamazepine, trifluoperazine, and tranylcypromine."
16 female BPD outpatients with severe behavior control problems but without major depression at the time of the study received the above medications. All but alprazolam improved the patient's condition. Alprazolam (Xanax) worsened behavioral dyscontrol (losing control of behavior). Patients taking carbamazepine (Tegretol) had a "marked decrease in the severity of behavioral dyscontrol." (Note: this landmark study by Dr. Cowdry and Dr. Gardner at NIMH has been invaluable to me for treating the BPD - it's one of the most important, informative and useful BPD studies ever performed)
Biol Psychiatry 1988 Sep;24(5):587-94
"Changes in EEG mean frequency associated with anxiety and with amphetamine challenge in BPD"
EEG is often abnormal in the BPD, further study with a stimulant showed minimal change, except in anxiety.
(Note: to me this reflects on attention deficit disorder and the generalized anxiety disorder in borderlines. The EEG is more often abnormal during dysphoric spells. The EEG measures surface readings, whereas deep brain structures are most likely involved in the BPD)
Can J Psychiatry 1988 Jun,33(5):350-4
"Biological markers in borderline personality disorders: an overview"
A summary of what is known, including REM latency (an indicator of sleep and brain function).
J Nerv Ment Dis 1988 Jan;176(1):40-4
"Factors associated with completed suicide in borderline personality disorder"
Highest risks included multiple hospitalizations, more suicide attempts, and severe suicidal behavior at admission. Expecting to go home frequently resulted in suicide.
Can J Psychiatry 1989 Feb;34(1):8-9
"Predictors of suicide in borderline personality disorder"
The most significant predictors of completed suicide were previous attempts and higher education.
Am J Psychiatry 1989 Apr;146(4):490-5
"Childhood trauma in borderline personality disorder"
81% had major childhood trauma. 71% had physical abuse. 68% had sexual abuse. 62% witnessed serious domestic violence. (Note: 1/5 statistically were NOT victims of childhood trauma)
Psychiatry Res 1989 Feb;27(2):111-5
"Cerebral structure in borderline personality disorder"
No evidence of structural brain pathology using CT scans.
1990-1992
Biol Psychiatry 1990 Aug 1;28(3):247-54
"CSF metabolites in borderline personality disorder compared with normal controls"
No different from non BPD. However, those with genuine suicide attempts had low levels.
Am J Psychiatry 1990 Apr;147(4):470-6
"The borderline diagnosis in adolescents: symptoms developmental history"
The following predict BPD in adolescents: disrupted attachments, maternal neglect, maternal rejection, grossly inappropriate parental behavior, number of mother and father surrogates, physical abuse, sexual abuse, and their families were chronically disrupted - particularly during early childhood.
Am Fam Physician 1990 May;41(5):1481-6
"Psychiatric implications of tattoos
Psychiatric disorders, such as antisocial personality disorder, drug or alcohol abuse and BPD, are frequently associated with tattoos. Finding a tatoo on physical examination should alert the physician to the possibility of an underlying psychiatric condition.
Am J Psychiatry 1990 Aug;147(8):1002-7
"Substance use in BPD"
67% of BPD inpatients also had substance use problems, particularly alcohol and hypnotics. When substance abuse was removed as a diagnostic criteria, 23% no longer met BPD criteria. The combination of BPD and substance use changes the severity and course of their illness. Substance use may play a role in BPD development.
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Last Updated( Feb 04, 2009 )
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reviewed by: Harry Croft, MD
Psychiatrist, HealthyPlace.com Medical Director
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