Medline Research on the Borderline Personality Disorder - BPD Medline Research

Written by Dr. Leland Heller

Am J Psychiatry 1991 Oct;148(10):1371-7
"The comorbidity of BPD and other DSM-III-R axis II personality disorders"
80% of those with BPD had at least one additional personality disorder. The authors wonder if there is a "general personality disorder concept" rather than a true BPD diagnosis.

Acta Psychiatr Scand 1991 Jul;84(1):72-7
"Personality disorders 2-5 years after treatment: a prospective follow-up study"
79 patients followed for 3 years had a "moderate symptom reduction," a "fair global outcome," and the "overall suicide are was low."

Am J Psychiatry 1991 Nov;148(11):1541-7
"A prospective follow-up study of so-called borderline children"
The childhood borderline diagnosis appears to be an antecedent of an array of adult personality disorders, but it is not associated with the adult BPD per se, nor with axis I diagnoses (such as depression).

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Arch Gen Psychiatry 1991 Dec;48(12):1060-4
"Cognitive-behavioral treatment of chronically parasuicidal borderline patients: (by Marsha Linehan and her group at the U of Washington in Seattle)"
A trial of DBT (dialectical behavior therapy) for chronically parasuicidal women studied for one year showed fewer incidences of parasuicide and less medically severe parasuicides, they were more likely to stay in individual therapy, and had fewer inpatient psychiatric days. No change in measures of depression, hopelessness, suicide ideation, or reasons for living although they did diminish in both the DBT and control groups over the study year.

1993-1995

Am J Psychiatry 1993 Dec;150(12):1836-42
"The impact of mother-child interaction on the development of BPD"
Maternal over-involvement and mismanagement and inappropriateness of maternal guidance and support were shown to only be a problem when the coexisted.

Am J Psychiatry 1993 Dec;150(12):1843-8
"Continuation pharmacotherapy of BPD with haloperidol and phenelzine"
Continuous treatment with haloperidol (Haldol) was ineffective except for irritability. Phenelzine offered modest improvement in irritability. (Note: my experience is Haldol works best on an "as needed" basis only - L Heller, MD)

J Clin Psychol 1993 Mar;49(2):277-81
"Features of borderline personality and violence" (from U of Southern California)
"It is concluded that borderline personality may predispose towards extreme forms of violence"

Am J Psychiatry 1993 Aug;150(8):1233-6
"Comorbidity of conduct disorder and personality disorders in an incarcerated juvenile population"
Conduct disorder in children and adolescents leads to antisocial personality disorder, not the borderline disorder.

Arch Psychiatr Nurs 1993 Jun;7(3):163-73
"Long-term consequences of childhood physical and sexual abuse"
"Physical and sexual abuse is associated with acute psychiatric symptomatology in children and may progress to a spectrum of psychiatric and medical disorders in adults, ranging from the extreme adaptive reactions seen in multiple personality disorder and refractory psychosis to intermediate adaptive reactions present in BPD to more delimited reactions manifest in chronic headaches and unremitting pelvic pain."

Am J Psychiatry 1993 Dec;150(12):1835-5
"Psychopathology in the families of children and adolescents with BPD"
"...significant family psychopathology is associated with the disorder."

Arch Gen Psychiatry 1993 Dec;50(12):971-4 (from Marsha Linehan)
"Naturalistic follow-up of a behavioral treatment for chronically parasuicidal borderline patients"
"In general, the superiority of DBT over treatment-as-usual, found in previous studies at the completion of 1 year of treatment, was retained during a 1-year follow-up."