|
Major Depressive Disorder |
OCD |
Panic Disorder |
Social Anxiety Disorder |
Generalized Anxiety Disorder |
PTSD |
|||||||
|
PAXIL |
Placebo |
PAXIL |
Placebo |
PAXIL |
Placebo |
PAXIL |
Placebo |
PAXIL |
Placebo |
PAXIL |
Placebo |
|
| CNS | ||||||||||||
| Somnolence |
2.3% |
0.7% |
— |
1.9% |
0.3% |
3.4% |
0.3% |
2.0% |
0.2% |
2.8% |
0.6% |
|
| Insomnia |
— |
— |
1.7% |
0% |
1.3% |
0.3% |
3.1% |
0% |
— |
— |
||
| Agitation |
1.1% |
0.5% |
— |
— |
— |
|||||||
| Tremor |
1.1% |
0.3% |
— |
1.7% |
0% |
1.0% |
0.2% |
|||||
| Anxiety |
— |
— |
— |
1.1% |
0% |
— |
— |
|||||
| Dizziness |
— |
— |
1.5% |
0% |
1.9% |
0% |
1.0% |
0.2% |
— |
— |
||
| Gastroin- | ||||||||||||
| testinal | ||||||||||||
| Constipation |
— |
1.1% |
0% |
— |
— |
|||||||
| Nausea |
3.2% |
1.1% |
1.9% |
0% |
3.2% |
1.2% |
4.0% |
0.3% |
2.0% |
0.2% |
2.2% |
0.6% |
| Diarrhea |
1.0% |
0.3% |
— |
|||||||||
| Dry mouth |
1.0% |
0.3% |
— |
— |
— |
|||||||
| Vomiting |
1.0% |
0.3% |
— |
1.0% |
0% |
— |
— |
|||||
| Flatulence |
1.0% |
0.3% |
— |
— |
||||||||
| Other | ||||||||||||
| Asthenia |
1.6% |
0.4% |
1.9% |
0.4% |
2.5% |
0.6% |
1.8% |
0.2% |
1.6% |
0.2% |
||
| Abnormal | ||||||||||||
| ejaculation1 |
1.6% |
0% |
2.1% |
0% |
4.9% |
0.6% |
2.5% |
0.5% |
— |
— |
||
| Sweating |
1.0% |
0.3% |
— |
1.1% |
0% |
1.1% |
0.2% |
— |
— |
|||
| Impotence1 |
— |
1.5% |
0% |
— |
— |
|||||||
| Libido | ||||||||||||
| Decreased |
1.0% |
0% |
— |
— |
||||||||
| Where numbers are not provided the incidence of the adverse events in patients treated with PAXIL was not >1% or was not greater than or equal to 2 times the incidence of placebo. | ||||||||||||
| 1. Incidence corrected for gender. | ||||||||||||