Practice Guideline for the Treatment of Patients With Bipolar Disorder (Revision)

page 11

PART C:
Future Research Needs

While a number of large, double-blind, controlled trials in bipolar disorder have been conducted since the publication of the first guideline on the treatment of bipolar disorder in 1994 (5), many significant questions remain regarding optimal use of the available treatments. The introduction of new pharmacotherapies, including newer anticonvulsants and atypical antipsychotics, has also led to a need to directly compare traditional and newer interventions. Moreover, fundamental questions remain to be addressed about the nature of bipolar disorder itself.

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