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Biederman J, Mick E, Faraone SV.
Pediatric Psychopharmacology Unit (ACC 725), Massachusetts General Hospital, Boston 02114, USA.
BACKGROUND:
The purpose of this study was to further evaluate the nature of the association
between major depression (MD) and
attention deficit hyperactivity disorder
(ADHD) by examining predictors of persistence of MD attending to issues of familiality, adversity and comorbidity.
METHODS:
Four years of follow-up of 76 depressed ADHD children were analyzed using
multivariate regression to determine predictors of persistent MD.
RESULTS:
Bipolar disorder and higher indices of interpersonal problems predicted MD
persistence. In contrast, school difficulty and ADHD-associated measures of
severity were not associated with persistent MD. Remission from ADHD was also
not statistically significantly associated with remission from MD.
CONCLUSIONS:
ADHD and MD had independent and distinct courses, indicating that
ADHD-associated MD reflects a depressive disorder and not merely demoralization.
LIMITATIONS:
This study may have reduced power due to stratification of our group of ADHD
boys with persistent and remitting MD.
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