FAQ: Topiramate (Topamax) for Treating Mood Disorders and PTSD - Psychiatric Uses of Topamax

Written by Ivan K. Goldberg, M.D.

The following publications are relevant to the psychiatric uses of topiramate:

Alao AO, Dewan MJ.
J Nerv Ment Dis. 2001 Jan;189(1):60-3.
Evaluating the tolerability of the newer mood stabilizers.
[No MEDLINE abstract available]

American Journal of Ophthalmology 2001, 132, 112-114
Presumed topiramate-induced bilateral acute angle-closure glaucoma.
[MEDLINE abstract]

Andrade C.
Bipolar Disord. 2001 Aug;3(4):211-212.
Confusion and dysphoria with low-dose topiramate in a patient with bipolar disorder.
[MEDLINE abstract]

Barbee JG.
Intwenational Journal of Eating Disorders, 2003, 33, 468-472. Topiramate in the treatment of severe bulimia nervosa with comorbid mood disorders: A case series. [MEDLINE abstract]

Berlant JL.
Journal of Clinical Psychiatry 2001, 62 (Suppl 17), 60-63.
Topiramate in posttraumatic stress disorder: preliminary clinical observations.
[MEDLINE abstract]

Berlant J.
Poster, presented at 39th Annual Meeting New Clinical Drug Evaluation Program (NIMH) Boca Raton, Florida, June 1-4, 1999.
Open-lable topiramate treatment of post-traumatic stress disorder.

Berlant J.
Journal of Clinica Psychiatry 2002, 63, 15-20.
Open-label topiramate as primary or adjunctive therapy in chronic civilian posttraumatic stress disorder: a preliminary report.
[MEDLINE abstract]

Besag FM.
Drug Safety 2001, 24, 513-536.
Behavioral effects of the new anticonvulsants.
[MEDLINE abstract]

Bowden CL.
Expert Opin Investig Drugs. 2001, 10, 661-671.
Novel treatments for bipolar disorder.
[MEDLINE abstract]

Brandes JL, Saper JR, Diamond M, et al.
Journal of the Americcan Medical Associagtion, 2004, 291,965-973.
Topiramate for migraine prevention: A randomized controlled trial.
[MEDLINE abstract]

Calabrese JR, Keck PE Jr, McElroy SL, Shelton MD.
Journal of Clinical Psychopharmacology 2001, 21, 340-342.
A pilot study of topiramate as monotherapy in the treatment of acute mania.
[MEDLINE abstract]

Calabrese JR, van Kammen DP, Shelton MD, et al
American Psychiatric Association Annual Meeting 1, New Research Abstracts NR680
Topiramate in severe treatment-refractory mania.
[No MEDLINE abstract available]
[MEDLINE abstract]

Calabrese JR, Shelton MD, Rapport DJ, Kimmel SE.
Journal of Clinical Psychiatry 2002, 63 (Suppl 3),5-9.
Bipolar disorders and the effectiveness of novel anticonvulsants.

Carpenter LL, Leon Z, Yasmin S, Price LH
Journal of Affective Disorders 2002 May; 69, 251-255.
Do obese depressed patients respond to topiramate? a retrospective chart review.
[MEDLINE abstract]

Cassano P, Lattanzi L, Pini S, et al.
Bipolar Disorders 2001, 3, 161.
Topiramate for self-mutilation in a patient with borderline personality disorder.
[No MEDLINE abstract available]

Chengappa K N, Gershon S, Levine J. Bipolar Disorders 2001, 3,215-232
The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder.
[MEDLINE abstract

Chengappa KN, Rathore D, Levine J, et al.
Bipolar Disorder. 1999 Sep;1(1):42-53.
Topiramate as add-on treatment for patients with bipolar mania.
[MEDLINE Abstract]

Chengappa KN, Levine J, Rathore D, Parepally H, Atzert R.
European Psychiatry 2001, 16, 186-190.
Long-term effects of topiramate on bipolar mood instability, weight change and glycemic control: a case-series.
[MEDLINE abstract]

Colom F, Vieta E, Benaberra A, et al
Journal of Clinical Psychiatry 2001, 62, 475-476.
Topiramate abuse in a bipolar patient with an eating disorder.
[MEDLINE abstract]

Davanzo P, Cantwell E, Kleiner J, et al.
Journal of the American Academy of Child and Adolescent Psychiatry 2001, 40, 262-263.
Cognitive changes during topiramate therapy.
[No MEDLINE abstract available]

De Leon OA. Harvard Review of Psychiatry. 2001, 9, 209-222.
Antiepileptic drugs for the acute and maintenance treatment of bipolar disorder.
[MEDLINE abstract]

DelBello MP, Kowatch RA, Warner J, et al.
Journal of Child and Adolescent Psychopharmacology, 2002, 12, 323-330.
Adjunctive topiramate treatment for pediatric bipolar disorder: a retrospective chart review.
[MEDLINE abstract]

Deutsch SI, Schwartz BL, Rosse RB, et al.
Clinical Neuropharmacology, 2003, 26, 199-206.
Adjuvant topiramate administration: a pharmacologic strategy for addressing NMDA receptor hypofunction in schizophrenia.
[MEDLINE abstract]

Doan RJ, Clendenning M.
Canadian Journal of Psychiatry 2000, 45, 937-938.
Topiramate and hepatotoxicity.
[No MEDLINE abstract available]

Drapalski AL, Rosse RB, Peebles RR, Schwartz BL, Marvel CL, Deutsch SI.
Clinical Neuropharmacology 2001, 24, 290-294.
Topiramate improves deficit symptoms in a patient with schizophrenia when added to a stable regimen of antipsychotic medication.
[MEDLINE abstract]

Dursun SM, Deakin JF.
J Psychopharmacol 2001 Dec;15(4):297-301.
Augmenting antipsychotic treatment with lamotrigine or topiramate in patients with treatment-resistant schizophrenia: A naturalistic case-series outcome study.
[MEDLINE Abstract]

Dursun SM, Devarajan S.
Canadian Journal of Psychiatry 2001, 46, 287-288.
Accelerated weight loss after treating refractory depression with fluoxetine plus topiramate: possible mechanisms of action?
[No MEDLINE abstract available]

Erfurth A, Kuhn G.
Neuropsychobiology 2000, 42 (Suppl 1), 50-51.
Topiramate monotherapy in the maintenance treatment of bipolar I disorder: Effects on mood, weight and serum lipids.
[MEDLINE abstract]

Felstrom A, Blackshaw S.
American Journal of Psychiatry, 2002, 159, 1246-1247 .
Topiramate for bulimia nervosa with bipolar II disorder. [No MEDLINE abstract available]

Gareri P, Falconi U, de Fazio P et al.
Progress in Neurobiology 2000, 61, 353-396.
Conventional and new antidepressants drugs in the elderly.
[MEDLINE abstract]

Ghaemi S N, Manwani S G, Katzow J J, Ko J Y, Goodwin F K.
Annals of Clinical Psychiatry 2001, 13, :185-189.
Topiramate treatment of bipolar spectrum disorders: A retrospective chart review.
[MEDLINE abstract]

Gitlin MJ.
Bulliten of the Menninger Clinic 2001 65, 26-40.
Treatment-resistant bipolar disorder.
[MEDLINE abstract]

Goldberg JF, Burdick KE.
Journal of Clinical Psychiatry 2001, 62 Suppl 14, 27-33.
Cognitive side effects of anticonvulsants.
[MEDLINE abstract]

Gordon A, Price LH
American Journal of Psychiatry 1, 156, 968-969.
Mood stabilization and weight loss with topiramate.
[No MEDLINE abstract available]

Grunze HC, Normann C, Langosh J et al.
Journal of Clinical Psychiatry 2001,62, 464-468.
Antimanic effacacy of topiramate in 11 patients in an open trial with an on-off-on design.
[MEDLINE abstract]

Jochum T, Bar KJ, Sauer H. J Neurology Neurosurgery and Psychiatry, 2002, 73, 208-209
Topiramate induced manic episode.
[No MEDLINE abstract available]

Khan A, Faught E, Gelliam F. et al.
Seizure 1, 8, 235-237.
Acute psychotic symptoms induced by topiramate.
[MEDLINE abstract]

Ketter TA et al.
Neurology 1, 53, (5, Suppl 2), S53-S67.
Positive and negative psychiatric effects of antiepileptic drugs in patients with seizure disorders.
[MEDLINE abstract]

Ketter TA et al.
Cell Mol Neurobiology 1, 19, 511-532.
Metabolism and excretion of mood stabilizers and new anticonvulsants.
[MEDLINE abstract]

Klufas A, Thompson D.
American Journal of Psychiatry. 2001, 158, 1736.
Topiramate-induced depression.
[No MEDLINE abstract available]

Komanduri R.
Journal of Clinical Psychiatry, 2003, 64, 612.
Two cases of alcohol craving curbed by topiramate.
[No MEDLINE abstract available]

Kupka RW, Nolen WA, Altshuler LL et al.
British Journal of Psychiatry, Suppliment 2001, 41, s177-s183.
The Stabley Foundation Bipolar Network. 2. Preliminary ssummary of demographics, ccourse of illness and response to novel treatments.
[MEDLINE abstract]

Kusumakar V, Yatham LN, O'Donovan CA, et al
American Psychiatric Association Annual Meeting 1, New Research Abstracts NR477
Topiramate in rapid-cycling bipolar women.
[No MEDLINE abstract available]

Letmaier M, Schreinzer D, Wolf R, Kasper S.
International Clinical Psychopharmacology. 2001, 16, 295-298.
Topiramate as a mood stabilizer.
[MEDLINE abstract]

Li X, Ketter TA, Frye MA
Journal of Affective Disorders 2002, May;69, 1-14.
Synaptic, intracellular, and neuroprotective mechanisms of anticonvulsants: are they relevant for the treatment and course of bipolar disorders?
[MEDLINE abstract]

McElroy SL, Suppes T, Keck PE, et al
Biological Psychiatry, 2000, 47, 1025-1033.
Open-label adjunctive topiramate in the treatment of bipolar disorders.
[MEDLINE abstract]

McIntyre RS, Mancini DA, McCann S, Srinivasan J, Sagman D, Kennedy SH.
Bipolar Disorders. 2002, 4, 207-213.
Topiramate versus bupropion SR when added to mood stabilizer therapy for the depressive phase of bipolar disorder: a preliminary single-blind study.
[MEDLINE abstract]

Maidment ID
Annals of Pharmacotherapy, 2002, 36(7):1277-1281 .
The use of topiramate in mood stabilization.
[MEDLINE abstract]

Marcotte D
Journal of Affective Disorders 1998, 50, 245-251.
Use of topiramate, a new anti-epileptic as a mood stabilizer.
[MEDLINE abstract]

Martin R, Kuzniecky R, Ho S, et al.
Neurology, 1, 15, 321-327.
Cognitive side effects of topiramate, gabapentin, and lamotrigine in healthy young adults.
[MEDLINE abstract]

Millson RC, Owen JA, Lorberg GW, Tackaberry L.
American Journal of Psychiatry 2002, 159, 675.
Topiramate for refractory schizophrenia.
[No MEDLINE abstract available]

Normann C, Langosch J, Schaerer LO et al.
American Journal of Psychiatry, 1, 156, 2014.
Treatment of acute mania with topiramate.
[No MEDLINE abstract available]

Pavuluri MN, Janicak PG, Carbray J.
Journal of Child and Adolesc Psychopharmacology, 2002, 12, 271-273.
Topiramate plus risperidone for controlling weight gain and symptoms in preschool mania.
[No MEDLINE abstract available]

Pecuch PW, Erfurth A.
Journal of Clinical Psychopharmacology 2001 21, 243-244.
Topiramate in the treatment of acute mania.
[ No MEDLINE abstract available]

Pinninti NR, Zelinski G.
Journal of Clinicsl Psychopharmacology, 2002, 22, 340 .
Does topiramate elevate serum lithium levels?
[No MEDLINE abstract available]

Post RM
Schizophrenia Research 1, 39, 153-158.
Comparative pharmacology or bipolar disorder and schizophrenia.
[MEDLINE abstract]

Post RM, Frye MA, Denicoff KD, et al.
Neuropsychopharmacology 1998 Sep;19(3):206-219
Beyond lithium in the treatment of bipolar illness.
[MEDLINE abstract]

Post RM, Frye MA, Denicoff KD et al.
Bipolar Disorders 2000, 2, 305-315. Emerging trends in the treatment of rapid cycling bipolar disorder: a selected review.
[MEDLINE abstract]

Schlatter FJ, Soutullo CA, Cervera-Enguix S.
Journal of Clinical Psychopharmacology 2001 21, 464-466.
First break of mania associated with topiramate treatment.
[No MEDLINE abstract available]

Tondo L, Hennen J, Baldessarini RJ.
Acta Psychiatr Scand. 2003 Jul;108(1):4-14.
Rapid-cycling bipolar disorder: effects of long-term treatments.
[MEDLINE abstract]

Vieta E, Gilabert A, Rodriguez A, et al.
Actas Esp Psiquiatr 2001, 29, 148-152.
Effectiveness and safety of topiramate in treatment-resistant bipolar disorder
[MEDLINE abstract]

Vieta E, Goikolea JM, OLivares JM, et al.
Journal of Clinical Psychiatry, 2003, 64, 834-839.
1-year follow-up of patients treated with risperidone and topiramate for a manic episode.

next: Lithium for Maintenance Treatment of Mood Disorders
~ bipolar disorder library
~ all bipolar disorder articles