American Ginseng - Usage, Dosage, Side-Effects of American Ginseng
How to Take It
Pediatric
This herb is not recommended for use in children because of its stimulant properties.
Adult
- Dried root: 500 to 2000 mg daily (can be purchased in 250 mg capsules).
- Tea/infusion: Pour 1 cup boiling water over 1 tsp finely chopped ginseng root. Steep for 5 to 10 minutes. Prepare and drink one to three times daily for three or four weeks.
- Tincture (1:5): 1 to 2 teaspoons
- Liquid extract (1:1): ¼ to ½ teaspoon
- Standardized extract (4% total ginsenosides): 100 mg twice daily
In healthy individuals who wish to increase physical or mental performance, to prevent illness, or to improve resistance to stress, ginseng should be taken in one of the above dosages for two to three weeks, followed by a break of two weeks.
advertisement |
For help recovering from an illness, the elderly should take 500 mg twice daily for three months. Alternatively, they may take the same dosage (500 mg twice daily) for a month, followed by a two-month break. This can then be repeated if desired.
Precautions
The use of herbs is a time-honored approach to strengthening the body and treating disease. Herbs, however, contain active substances that can trigger side effects and interact with other herbs, supplements, or medications. For these reasons, herbs should be taken with care, under the supervision of a practitioner knowledgeable in the field of botanical medicine.
Both American and Asian ginsengs are stimulants and may cause nervousness or sleeplessness, particularly if taken at high doses. Other reported side effects include high blood pressure, insomnia, restlessness, anxiety, euphoria, diarrhea, vomiting, headache, nosebleed, breast pain, and vaginal bleeding. To avoid hypoglycemia (low blood sugar), even in non-diabetics, ginseng should be taken with food.
The American Herbal Products Association (AHPA) rates ginseng as a class 2d herb, which indicates that specific restrictions apply. In this case, hypertension (high blood pressure) is the specific restriction. People with hypertension should not take ginseng products without specific guidance and instruction from a qualified practitioner. At the same time, people with low blood pressure as well as those with an acute illness or diabetes (because of the risk of a sudden drop in blood sugar), should use caution when taking ginseng.
Safety of taking ginseng during pregnancy is unknown; therefore, it is not recommended when pregnant or breast feeding.
Ginseng should be discontinued at least 7 days prior to surgery. This is for two reasons. First, ginseng can lower blood glucose levels and, therefore, create problems for patients fasting prior to surgery. Also, ginseng may act as a blood thinner, thereby increasing the risk of bleeding during or after the procedure.
Possible Interactions
If you are currently being treated with any of the following medications, you should not use ginseng without first talking to your healthcare provider:
Blood Thinning Medications
There have been reports that ginseng may possibly decrease the effectiveness of the blood-thinning medication, warfarin. In addition, ginseng may inhibit platelet activity and, therefore, should probably not be used with aspirin either.
Caffeine
While taking ginseng, it is wise to avoid caffeine or other substances that stimulate the central nervous system because the ginseng may increase their effects, possibly causing nervousness, sweating, insomnia, or irregular heartbeat.
Ginseng and Haloperidol
Ginseng may exaggerate the effects of this anti-psychotic medication, so they should not be taken together.
Morphine
Ginseng may block the pain killing effects of morphine.
Phenelzine and other MAOIs for Depression
There have been reports of a possible interaction between ginseng and the antidepressant medication, phenelzine (which belongs to a class known as monoamine oxidase inhibitors [MAOIs]), resulting in symptoms ranging from manic-like episodes to headache and tremulousness.
back to: Herbal Treatments Homepage
Supporting Research
Adams LL, Gatchel RJ. Complementary and alternative medicine: applications and implications for cognitive functioning in elderly populations. Alt Ther. 2000;7(2):52-61.
Ang-Lee MK, Moss J, Yuan C-S. Herbal medicines and perioperative care. JAMA. 2001;286(2):208-216.
Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol. 1999;58(11):1685-1693.
Bahrke M, Morgan P. Evaluation of the ergogenic properties of ginseng. Sports Medicine. 1994;18:229 - 248.
Blumenthal M, Goldberg A, Brinckman J, eds. Herbal Medicine: Expanded Commission E Monographs. Newton, Mass: Integrative Medicine Communications; 2000.
Briggs CJ, Briggs GL. Herbal products in depression therapy. CPJ/RPC. November 1998;40-44.
Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, Ore: Eclectic Medical; 1998:77.
Bucci LR. Selected herbals and human exercise performance. Am J Clin Nutr. 2000;72(2 Suppl):624S-636S.
Carai MAM, Agabio R, Bombardelli E, et al. Potential use of medicinal plants in the treatment of alcoholism. Fitoterapia. 2000;71:S38-S42.
Cardinal BJ, Engels HJ. Ginseng does not enhance psychological well-being in healthy, young adults: Results of a double-blind, placebo-controlled, randomized clinical trial. J Am Diet Assoc. 2001;101:655-660.
Caso Marasco A, Vargas Ruiz R, Salas Villagomez A, Begona Infante C. Double-blind study of a multivitamin complex supplemented with ginseng extract. Drugs Exp Clin Res. 1996;22(6):323-329.
Duda RB, Zhong Y, Navas V, Li MZ, Toy BR, Alavarez JG. American ginseng and breast cancer therapeutic agents synergistically inhibit MCF-7 breast cancer cell growth. J Surg Oncol. 1999;72(4):230-239.
Ernst E. The risk-benefit profile of commonly used herbal therapies: ginkgo, St. John's wort, ginseng, echinacea, saw palmetto, and kava. Ann Intern Med. 2002;136(1):42-53.
Ernst E, Cassileth BR. How useful are unconventional cancer treatments? Eur J Cancer. 1999;35(11):1608-1613.
Fugh-Berman A. Herb-drug interactions. Lancet. 2000;355:134-138.
Gyllenhaal C, Merritt SL, Peterson SD, Block KI, Gochenour T. Efficacy and safety of herbal stimulants and sedatives in sleep disorders. Sleep Med Rev. 2000;4(2):229-251.
Han KH, Choe SC, Kim HS, et al. Effect of red ginseng on blood pressure in patients with essential hypertension and white coat hypertension. Am J Chin Med. 1998;26(2):199-209.
Harkey MR, Henderson GL, Gershwin ME, Stern JS, Hackman RM. Variability in commercial ginseng products: an analysis of 25 preparations. Am J Clin Nutr. 2001;73:1101-1106.
Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. 2000;57(13):1221-1227.
Izzo AA, Ernst E. Interactions between herbal medicines and prescribed drugs: a systematic review. Drugs. 2001;61(15):2163-2175.
Kelly GS. Nutritional and botanical interventions to assist with the adaptation to stress. Alt Med Rev. 1999;4(4):249-265.
Lieberman HR. The effects of ginseng, ephedrine, and caffeine on cognitive performance, mood and energy. Nutr Rev. 2001;59(4):91-102.
Liu J, Burdette JE, Xu H, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem. 2001;49(5):2472-2479.
Lyon MR, Cline JC, Totosy de Zepetnek J, et al. Effect of the herbal extract combination Panax quinquefolium and Ginkgo biloba on attention-deficit hyperactivity disorder: a pilot study. J Psychiatry Neurosci. 2001;26(3):221-228.
Mantle D, Lennard TWJ, Pickering AT. Therapeutic applications of medicinal plants in the treatment of breast cancer: a review of their pharmacology, efficacy and tolerability. Adverse Drug React Toxicol Rev. 2000;19(3):2223-240.
Mantle D, Pickering AT, Perry AK. Medicinal plant extracts for the treatment of dementia: a review of their pharmacology, efficacy, and tolerability. CNS Drugs. 2000;13:201-213.
Miller LG. Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. Arch Intern Med. 1998;158(20):2200 - 2211.
Murphy LL, Cadena RS, Chavez D, Ferraro JS. Effect of American ginseng (Panax quinquefolium) on male copulatory behavior in the rat. Physiol Behav. 1998;64:445 - 450.
O'Hara M, Kiefer D, Farrell K, Kemper K. A review of 12 commonly used medicinal herbs. Arch Fam Med. 1998;7(6):523-536.
Ott BR, Owens NJ. Complementary and alternative medicines for Alzheimer's disease. J Geriatr Psychiatry Neurol. 1998;2:163-173.
Pizzorno JE, Murray MT, eds. Textbook of Natural Medicine. New York, NY: Churchill-Livingstone; 1999:847-855.
Scaglione F, Cattaneo G, Alessandria M, Cogo R. Efficacy and safety of the standardized ginseng extract G 115 for potentiating vaccination against common cold and/or influenza syndrome. Drugs Exp Clin Res. 1996;22(20:65-72.
Sotaniemi EA, Haapakoski E, Rautio A. Ginseng therapy in non - insulin-dependent diabetic patients. Diabetes Care. 1995;18(10):1373 - 1375.
Sung J, Han KH, Zo JH, Park HJ, Kim CH, Oh B-H. Effects of red ginseng upon vascular endothelial function in patients with essential hypertension. Am J Chin Med. 2000;28(2):205-216.
Takahashi M, Tokuyama S. Pharmacological and physiological effects of ginseng on actions induced by opioids and psychostimulants. Meth Find Exp Clin Pharmacol. 1998;20(1):77-84.
Tode T, Kikuchi Y, Hirata J, et. al. Effect of Korean red ginseng on psychological functions in patients with severe climacteric syndromes. Int J Gynaecol Obstet. 1999;67:169-174.
Vaes LP, Chyka PA. Interactions of warfarin with garlic, ginger, ginkgo, or ginseng: nature of the evidence. Ann Pharmacother. 2000;34(12):1478-1482.
Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. A systematic review of randomized clinical trials. Eur J Clin Pharmacol. 1999;55:567-575.
Vuksan V, Sievenpiper JL, Koo VYY, et al. American ginseng (Panax quinquefolius L) reduces postprandial glycemia in nondiaetic subjects and subjects with type 2 diabetes mellitus. Arch Intern Med. 2000;160:1009-1013.
Vuksan V, Sievenpiper JL, Xu Z, et al. Konjac-mannan and American ginseng: emerging alternative therapies for type 2 diabetes mellitus. J Am Coll Nutr. 2001;20(5):370S-380S.
Vuksan V, Stavro MP, Sievenpiper JL, et al. Similar postprandial glycemic reuctions with escalation of dose and administration time of American ginseng in type 2 diabetes. Diabetes Care. 2000;23:1221-1226.
Wargovich MJ. Colon cancer chemoprevention with ginseng and other botanicals. J Korean Med Sci. 2001;16 Suppl:S81-S86.
Wiklund IK, Mattsson LA, Lindgren R, Limoni C. Effects of a standardized ginseng extract on quality of life and physiological parameters in symptomatic postmenopausal women: a double-blind, placebo-controlled trial. Int J Clin Pharm Res. 1999;19(3):89-99.
Yun TK, Choi SY. Preventive effect of ginseng intake against various human cancers: A case-control study on 1987 pairs. Cancer Epidemiol Biomarkers Prev. 1995;4:401-408.
Ziemba AW, Chmura J, Kaciuba-Uscilko H, Nazar K, Wisnik P, Gawronski W. Ginseng treatment improves psychomotor performance at rest and during graded exercise in young athletes. Int J Sports Nutr. 1999;9(4):371-377.
back to: Herbal Treatments Homepage
reviewed by:
Harry Croft, MD (Psychiatrist)
Medical Director, HealthyPlace.com
Created on December 14, 2008 Last Updated on September 22, 2011
In Alt. Mental Health
Who's Online

