New Data Show Early Non-Response to Antipsychotic Treatment May Be Strong Predictor of Subsequent Non-Response for People with Schizophrenia

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(i) APA Practice Guidelines. Am J Psychiatry. 2004. (ii) Maguire GA. Am J Health Syst Pharm. 2002;59(17 suppl 5):S4-S11. (iii) Modestin J, Ammann R. Schizophr Bull. 1996;22(1):69-82. (iv) Olfson M, et al. Psychiatr Serv. 1999;50(5):667-673.

(v) Lieberman JA, et al. J Clin Psychopharmacol. 1998;18(2 suppl 1):20S-24S.

(vi) APA. DSM-IV-TR; 2000.

(vii) Agid O, Kapur S, Arenovich T, Zipursky RB. Delayed-onset hypothesis of antipsychotic action. A hypothesis tested and rejected. Arch Gen Psychiatry 2003;60:1228-1235; Leucht S, Busch R, Hamann J, et al. Early-onset hypothesis of antipsychotic drug action: A hypothesis tested, confired and extended. Biol Psychiatry 2005;57:1543-1549; Correll CU, Malhotra AK, Kaushik S, et al. Early prediction of antipsychotic response in schizophrenia. J Clin Psychopharmacol 2003;26:554-559.

(viii) Weiden P, Scheifler P, Diamond R, et al. Breakthroughs in Antipsychotic Medications. New York: W.W. Norton & Company, 1999.

(ix) "Schizophrenia: What You Need to Know" Mental Health America http://www.mentalhealthamerica.net/go/information/get- info/schizophrenia/schizophrenia-what-you-need-to-know/schizophrenia-what-you- need-to-know. Accessed March 14, 2007

(x) PRODIGY Knowledge Guidance: Schizophrenia. http://cks.library.nhs.uk/schizophrenia/extended_information/background_inform ation. Accessed March 14, 2007

(xi) "Schizophrenia: What You Need to Know" Mental Health America http://www.mentalhealthamerica.net/go/information/get- info/schizophrenia/schizophrenia-what-you-need-to-know/schizophrenia-what-you- need-to-know. Accessed March 14, 2007.

(xii) The World Health Report 2001: Mental Health - New Understanding, New Hope. World Health Organization, 2001. Available at http://www.who.int/whr/2001/chapter3/en/index1.html. Accessed March 14, 2007.

Source: PRNewswire-FirstCall

Last updated: 04/07

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