Drug Firms Eye Fat Profits from New Obesity Pills

By Ben Hirschler, European Pharmaceuticals Correspondent

(January 16, 2006) -- A marijuana joint might seem an odd starting point in the search for weight-loss secrets.

Yet a compound switching off the same brain circuits that make people hungry when they smoke cannabis looks set to become the world's first blockbuster anti-obesity medicine, with sales tipped by analysts to top $3 billion (1.7 billion pounds) a year.

Sanofi-Aventis' Acomplia, or rimonabant, which could be approved by U.S. regulators as early as next month, is the first of a new wave of treatments that may spell fat profits for some pharmaceutical companies.

Another two experimental drugs from Arena Pharmaceuticals and Alizyme, with different mechanisms of action, have also produced promising clinical results in recent weeks, prompting some investors to start laying big bets on weight-loss medicine.

It is a risky area, however.

Slimming pills have had a chequered history, due to modest effectiveness and adverse side effects -- most notoriously with the diet drug combination "fen-phen", which was linked to heart-valve problems and has cost Wyeth more than $21 billion in provisions related to patient claims.

But past upsets have not deterred drug manufacturers from investing heavily in a new generation of possible winners.

MORE DRUGS IN PIPELINE

Jonathan de Pass, chief executive of specialist consultancy Evaluate, calculates there are now 26 new drugs in clinical trials for obesity and a further 32 in early-stage development.

In addition, at least half a dozen diabetes medicines are being tried out as treatments for reducing weight.

The potential market is large in every respect.

Overweight Kids: A Growing Problem Kids across the country eat too much and exercise too little. Doctors say that’s a formula for weight problems, obesity and future health problems.

The World Health Organisation estimates more than 1 billion people in the world are overweight and, if current trends continue, that number will reach 1.5 billion by 2015.

Of the current total, more than 300 million already rank as obese, putting them at substantial risk of heart disease, stroke, type 2 diabetes, respiratory problems and some cancers.

Worryingly, the problem is also starting to spread rapidly in developing countries, including parts of Africa, and the western Pacific islands of Nauru and Tonga hold the dubious distinction of having the highest percentage rates of obesity in the world.

Given the scale of the problem, the arrival of new weight-loss drugs will be greeted with some excitement -- but they may also pose a dilemma.

Dr Timothy Armstrong of the WHO's department of chronic diseases believes medication can help only a very small minority of patients and will not impact the overall obesity epidemic.

"It's not a panacea," he said. "Drugs don't have a role in preventing obesity in the wider population, where interventions around physical activity and diet are far more cost-effective."

Why Do People Overeat? Dr. Rick Kausman is a nutritionist and runs his own eating behavior clinic in Melbourne, Australia. Kausman says "Being hungry is a lot like being in love. If you're not sure, you're probably not." He encourages people to take back control by checking to see whether or not that craving for food really is about hunger. Guilt should be banished along with pejorative terms such as junk food. Instead, allow yourself to enjoy a scone with jam and lashings of cream. Listen to this audio show.

Professor Luc Van Gaal of Belgium's University Hospital Antwerp, the lead investigator for one of the main clinical studies for Acomplia, sees things rather differently.

He argues doctors must accept that dieting and exercise alone often produce disappointing results, leaving patients at risk of falling seriously ill.

"Drug therapy is not the answer for every obese person in the street, but for certain patients who are running a risk, pharmacological therapy can help," he said.

SIDE EFFECTS

Today, there are two main obesity medicines on the market -- Roche's Xenical, which works by limiting fat absorption, and Abbott Laboratories' Meridia/Reductil, which suppresses appetite.

Both can have adverse side effects, however. Xenical can cause excess gas and oily discharge, while Meridia may increase blood pressure. As a result, sales of both drugs are modest, at $460 million and $300 million respectively in 2004.

GlaxoSmithKline hopes to win backing from a U.S. panel later this month for its own low-dose, low-side effect version of Xenical that would be sold without prescription -- although many industry experts still doubt it will become a major seller.

By contrast, the consensus forecast from analysts for peak sales of Acomplia is $3.1 billion, according to Evaluate, with some predictions topping $5 billion.

Just how big the drug will be, however, depends on the terms of use that Sanofi agrees with healthcare regulators.

The company hopes to prove that Acomplia specifically reduces key cardiovascular risk factors, since a simple obesity label may not be enough secure widespread reimbursement from governments and insurers.

Side effects could also be an issue. While patients on Acomplia have lost around 7 kg (15 lb) in body weight over two years, concerns remain about its potential impact on mood.

Still, rivals clearly think Sanofi is onto something big, with Merck & Co, Pfizer and Bristol-Myers Squibb among a clutch of companies now developing similar cannabinoid receptor blocking drugs.

Last updated: 01/06.

Related Information

• FDA Warns Consumers about Brazilian Diet Pills Found to Contain Active Drug Ingredients
• Positive Body Image
• Compulsive Overeating:
  Dealing With The Feelings and How To Treat It
• Binge Eating and Self-Esteem
• Impact of Obesity and Dieting
• How to Figure Out If Your Child is Overweight
• Helping Your Teen with Weight Management
• Impact of Anorexia, Bulimia and Obesity on the Gynecologic Health of Adolescents

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