What About Side
Effects From Antipsychotic Medications?
Antipsychotic drugs, like
virtually all medications, have unwanted effects along with their beneficial
effects. During the early phases of antipsychotic drug treatment, patients may
be troubled by side effects such as drowsiness, restlessness, muscle spasms,
tremor, dry mouth, or blurring of vision. Most of these can be corrected by
lowering the dosage or can be controlled by other medications. Different
patients have different treatment responses and side effects to various
antipsychotic drugs. A patient may do better with one drug than another.
The long-term side effects of antipsychotic drugs may pose a considerably
more serious problem. Tardive dyskinesia (TD) is a disorder characterized by
involuntary movements most often affecting the mouth, lips, and tongue, and
sometimes the trunk or other parts of the body such as arms and legs. It occurs
in about 15 to 20 percent of patients who have been receiving the older,
typical antipsychotic drugs for many years, but TD can also develop
in patients who have been treated with these drugs for shorter periods of time.
In most cases, the symptoms of TD are mild, and the patient may be unaware of
the movements.
Antipsychotic medications developed in recent years all appear to have a
much lower risk of producing TD than the older, traditional antipsychotics. The
risk is not zero, however, and they can produce side effects of their own such
as weight gain. In addition, if given at too high of a dose, the newer
medications may lead to problems such as social withdrawal and symptoms
resembling Parkinsons disease, a disorder that affects movement.
Nevertheless, the newer antipsychotics are a significant advance in treatment,
and their optimal use in people with schizophrenia is a subject of much current
research.
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